From Selection you can begin exploring concepts in Coremine Medical. The process is like most search engines, but also includes some more nuanced features. The simplest example is to select one concept to explore. But you can also select several concepts to explore simultaneously. Another nuance is the ability to limit the selection of concepts to specific categories. In addition, there is the possibility that the concept you wish to explore is missing from Coremine Medical dictionaries, in which case you will be prompted to report the concept to Coremine Medical experts to be considered for possible inclusion in future dictionaries.
Finally, there is an option to select among the names of experts. To illustrate this idea, notice that an example concept, "Influenza," and an example expert "Edwards, RG" are shown in connection with Selection. Concepts and Experts are two fundamentally different approaches offered by Coremine Medical: you can either select concepts from biomedical dictionaries or authors of scientific papers (Biomedical experts).
As suggestions are shown while typing in the Selection input field, a text link ("Filter...") appears below the concept entry field (to the right of the text Choose one of the concepts to explore:). If you choose to open the filter you will see a list of concept categories. By default, concepts in all categories are used to provide a match to the text you type. If you wish to limit concepts to a specific set of categories you can do so by using the associated check boxes. concept suggestion categories include:
Each category is a list of biomedically relevant concepts and associated synonyms. The source of each concept type is described below under the heading Categories.
Once having changed settings, click the "Update suggestions"
link to apply the filter to the suggestions that appear in the concept entry field. The filter will remain in effect throughout your explorations session unless you choose to change it.
There are times when a legitimate and useful concept does not appear among the suggestions offered while typing a concept into the input field. A dialog box will appear whenever Coremine Medical is unable to suggest a concept in response to the text you have typed. In this dialog are suggestions for how a match might be achieved, but also a text-link stating "please report the missing medical concept or biomedical expert to us here!"
The link will open a new dialog box that allows you to submit the suggested concept to Coremine Medical experts for review and possible inclusion in and updated dictionary. The dialog box includes fields that allow you to write the missing search phrase and a comment. There is also a menu that can be used to select a concept category that you believe is appropriate for the concept. In addition, you can enter an email address if you would like to be contacted regarding the review status of the concept you submitted.
Although Coremine Medical dictionaries are drawn from sources like the Medical Subject Headings (MeSH) thesaurus of concepts and other large dictionaries addressing biomedical concepts, some important concepts may not be included in these source materials. Sometimes even fairly common concepts are missing because these may differ from a stricter use applied by experts. Other times there are acronyms or other variants used by one group of specialists that are unknown to another group. We appreciate the input of our users any time a missing concept is brought to our attention.
If you know the name of a Biomedical expert, you can use Coremine Medical to search for that expert and colleagues.
Alternatively, if you wish to find an expert in a given field, use keywords to search within the field and then view the Biomedical experts list to be discussed in the section on the Focus panel under Extracted Knowledge.
To search for an expert from the selection menu, begin by typing the last name of the expert. A list of suggestions will appear. Add first name initials if you need to refine the search to fewer suggestions.
If the expert name does not appear you may choose to report the missing name to our experts for evaluation, as described above regarding missing concepts for concepts.
The icons under the text "Categories (click to disable)" are "switches" that allow you to limit the scope of your search results to concepts within various concept categories.
To illustrate the function of these category filters, consider the question "how is breast cancer treated?" To explore possible answers to this question, and to avoid suggestions outside of its scope, you can choose to leave only the Drug and Procedure categories active (click all other categories to "gray out" their icons). Now you can type "breast cancer" in the Selection field and you will see the concept "Breast carcinoma" suggested as a match.
The concept map generated by this process would show one Disease concept (Breast Carcinoma) and five concepts each from Drugs and Procedure categories. The search concept will always be included, even if its category is "deselected" (in the case of this example, Breast Carcinoma, by virtue of it being the search concept, is included even though Disease category concepts are excluded from search results).
Note that these buttons affect the types of concepts that will be retrieved once you have clicked the Explore button and launched a search. The Categories buttons do NOT change the concept suggestions seen during concept selection (see Select concepts from specific concept categories for a description of that process).
The concepts used by Coremine Medical to identify concepts and other entities in scientific and popular literature make up dictionaries of recognized concepts compiled from trusted sources. Concepts can be assigned to higher-order groupings and Coremine Medical operates with twelve such categories that can be used to define your search.
Below is a list of the biomedical concept categories used by Coremine Medical and an indication of the sources used:
Category | Description |
---|---|
Disease - UMLS(MeSH, DO) | |
Drug - Drug Bank | |
Symptom - UMLS | |
Procedure - UMLS | |
Anatomy - MeSH | |
Food - USDA | |
MeSH - MeSH | |
Chemical - PubCham | |
Cellular Component - GO | |
Biological Process - GO | |
Molecular Funtoin - GO | |
Gene/Protein - EG, GP, HG, iP, RS, Ug, UM, ZM | |
Traditional Chinese Medisin | |
Cell-Lines |
Abbreviation | Explanation |
---|---|
DO | Disease Ontology |
EG | Entrez Gene |
Drug Bank | Drug Bank |
GO | Gene Ontology |
GP | GoldenPath |
HG | HomoloGene |
iP | iProclass |
MeSH | Medical Subject Headings |
RS | RefSeq (*.protein.faa.gz files) |
UG | UniGene |
UMLS | Unified Medlical Language System (an aggregator of primary sources including MeSH and DO) |
UP | UniProt |
USDA | United States Department of Agriculture |
ZM | ENZYME |